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Tau protein undergoes conformational changes and abnormal phosphorylation, which leads to its separation from microtubules, forming neurofibrillary tangles

Activation of GLP-1R reduced NTG-induced c-fos expression in the TNC In addition to CGRP, we also detected alterations in c-fos expression in the TNC, which is a reliable marker of neuronal activation and is considered another mediator of central sensitization

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