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A pooled analysis published in the National Institutes of Health PMC archive found tirzepatide reduced body weight more than semaglutide across different study designs, and a journal review summarized by the American College of Cardiology reported significantly greater weight loss with tirzepatide

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Zhou et al., 2016)

Abstract Purpose of Review To discuss current literature and provide practical recommendations for the safe and effective use of glucagon-like peptide 1 receptor agonists (GLP-1 RA) in people with inflammatory bowel disease (IBD) and type 2 diabetes (T2D) and/or obesity

Adjusted mean weight loss was highest in the tirzepatide group (19.52 0.70 kg), followed by semaglutide (16.63 0.73 kg) and liraglutide (13.18 0.74 kg)