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Real-world drug use almost always reveals a wider spectrum of effects than controlled clinical trials, especially for therapies that significantly alter metabolism and energy balance

This leads to increased bile acids in the intestinal lumen, which then trigger Takeda G-protein-coupled receptor 5 (TGR5) on L-cells, stimulating the production and release of GLP-1 (Thomas et al., 2009

These cells are critical regulators of glomerular perfusion and pressure and are intimately involved in a physiological process known as tubuloglomerular feedback (TGF) (10), which is detailed below

Peptides 2020;125:170213.ArticlePubMedPMC 19

Most side effects can be managed by starting with a lower dose and gradually increasing as your body adjusts to the medication

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