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The 2.4 mg group lost the most weight, which means that among adults suffering from overweight or obesity and T2DM, SMG 2.4 mg once a week has achieved significant clinically significant weight loss (99)

Dose adjustments, switching to complementary peptides like tirzepatide, or adding a dual-compound can restore progress

Common temporary effects may include mild digestive symptoms as the body adapts

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Greater exercise volume results in greater reductions in A1C than lower-volume programs (Umpierre et al., 2011)

But its important to be clear that these medications alone are not a cure for chronic obesity, nor does every individual respond to them in the same way