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When switching, it is important to emphasise that treatment burden will not increase and that if gastrointestinal adverse effects occur, they are typically transient

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Bile acids could alter gut permeability through the G-protein-coupled bile acid receptor (TGR5), a cell surface receptor, which occurs at a high level expression in the human placenta and spleen and is also found in multiple tissues such as the lung, liver, adipocytes, and the gastrointestinal tract (152)