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Body aches at 10 mg are more likely to stem from muscle loss and rapid musculoskeletal changes than from dehydration alone
The flexibility in dosing allows for better management of adverse effects, ensuring a safer treatment protocol
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Compared to dulaglutide, tirzepatide at both 5 and 10 mg doses has shown improved glycemic control as well as weight management with similar levels of tolerability
49 However, an interim analysis at 72 weeks of a phase 3 trial of semaglutide 2.4 mg once weekly for MASH showed histological improvements, including resolution of fibrosis, reduction of liver fibrosis and resolution of steatohepatitis in a significant number of patients
