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Notably, a dose-dependent increase in heart rate, peaking at 24 weeks, subsequently decreased [19]

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Additionally, it extends the C-terminal with a sequence of exenatide, and thirdly, it has an attached fatty acid side chain, similar to semaglutide, to prolong its half-life [16]
Pre-existing conditions can influence safety

A recent meta-analysis of 18 studies concluded that this effect is significant and warrants further investigation

Risk of lactic acidosis increases in patients with kidney disease, liver disease, or excessive alcohol use