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Reducing Your Risk of Gallstones on GLP-1 Therapy Whilst the increased risk of gallstone formation associated with GLP-1 receptor agonist therapy cannot be entirely eliminated, several strategies may help reduce this risk

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On Tri-Agonism What distinguishes GL-3 RT from single-receptor (GLP-1) and dual-receptor (GLP-1/GIP) agonists is the addition of glucagon receptor activity

In patients with diabetes, beta-blockers can also mask symptoms of hypoglycaemia, which is an additional consideration if retatrutide is used alongside glucose-lowering agents There are currently no published pharmacokinetic or pharmacodynamic interaction data specific to retatrutide with antihypertensive agents, as the drug remains investigational

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doi: 10.1016/j.metabol.2020.154167