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A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis
GLP-1/GIP dual agonists are thought to be more effective at lowering blood glucose and body weight than GLP-1s alone
103 However, after birth, these mice exhibit islet beta-cell failure and hyperglycaemia occurs within a few days followed by diabetic ketoacidosis and subsequent death
It's a decision to defer and compound these different diseases, including type 2 diabetes, cardiovascular disease, kidney disease, liver disease, obstructive sleep apnea and even certain types of cancer, she added
This evolutionary progression reflects systematic optimization of drug efficacy, duration of action, and tolerability profiles
10.1056/NEJMoa1612917 [DOI] [PMC free article] [PubMed] [Google Scholar] 12.ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al
