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NICE in the UK recommends a maximum of two years for semaglutide (Wegovy), though no such limit exists for tirzepatide (Mounjaro)

The combination of peptide-driven fat loss with exercise-driven muscle preservation produces more favorable metabolic profiles than either intervention alone

For others, hunger returns suddenly, and the weight slowly creeps back

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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Weiss N.S., van Vliet M.N., Limpens J., Hompes P.G.A., Lambalk C.B., Mochtar M.H., van der Veen F., Mol B.W.J., van Wely M