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Experiments using human samples were approved by French Institutional Review Board (Comit de Protection des Personnes, Paris Ile-de-France 5 and Commission Nationale de lInformatique et des Liberts)

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For example, GLP-1R in adipocytes can directly regulate apoptosis and preadipocyte proliferation by activating the adenylate cyclase/cyclic adenosine monophosphate (AC/cAMP) signaling pathway and various cell signaling cascades, including extracellular signal-regulated kinase (ERK), protein kinase C (PKC), and protein kinase B (AKT) [41,46]
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