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We also estimated 10-year CVD risks utilizing the BMI-based Framingham CVD risk scores

The association between glucagonlike peptide1 receptor agonists (GLP1 RAs) and depression remains uncertain due to contradictory evidence

In patients with cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization for heart failure or all-cause mortality vs sitagliptin, but tirzepatide offered no additional benefit over semaglutide.

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However, prospective real-world studies directly comparing these interventions are limited