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Mesinovic, J

GLP-1 Receptor Modulation Appetite Regulation and Glucose Control Activation of glucagon-like peptide-1 (GLP-1) receptors by GLP3 contributes to multiple metabolic effects observed in clinical studies[6]: Delayed gastric emptying , resulting in prolonged satiety and reduced meal size Suppression of appetite through actions on hypothalamic feeding centers Enhancement of glucose-stimulated insulin secretion from beta cells Inhibition of glucagon secretion from pancreatic alpha cells during hyperglycemic states Potential neuroprotective effects through central nervous system GLP-1 receptor engagement Phase 1b studies in humans with type 2 diabetes confirmed that GLP3 significantly delays gastric emptying, with effects persisting throughout the 12-week treatment period, suggesting limited tachyphylaxis development compared to some other GLP-1 receptor agonists[7]

Fibrosis is the primary prognostic factor affecting both complications and survival in MAFLD

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James G, Kim J, Mellstrm C, Ford KL, Jenkins NC, Tsang C et al (2022) Serum potassium variability as a predictor of clinical outcomes in patients with cardiorenal disease or diabetes: a retrospective UK database study