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No statistically significant differences were observed in the proportions of patients who discontinued treatment because of adverse events when tirzepatide 5, 10, and 15 mg were compared with GLP-1 RA comparators, apart from tirzepatide 10 and 15 mg versus placebo

Body weight, food intake, fat mass, and lean mass were evaluated during treatment

Less Common / Serious Side Effects Palpitations Hypotension (rare, usually with high doses or other antihypertensives) Gingival hyperplasia (rare) Reflex tachycardia (minimal compared to other dihydropyridines) 5

Also Known As: LY3437943

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A multicenter, randomized, phase 3b trial, found that once-daily oral semaglutide taken at higher doses of 25mg and 50mg improved regulation of blood sugar levels and weight loss compared to the standard 14 mg dose.