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The effect on gastric emptying diminishes over time with continuous exposure, primarily with long-acting agents that result in tachyphylaxis due to sustained receptor agonism [48, 53]

This hepatic insulin resistance increases gluconeogenesis, leading to elevated glucose and insulin levels [17]

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Concerns about Ozempic-related vision problems surfaced in July 2024 after a Harvard study indicated a significantly increased risk of NAION among semaglutide users