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PubMed Central

Despite exenatide showing a higher reported number of reactions compared to liraglutide (2539:1981), the associations with acute pancreatitis events were weaker, which was also observed in cases of pancreatic cancer (Cao et al., 2023)

For AD specifically, given the well-established effects of GLP-1 RAs on tau hyperphosphorylation, we recommend that future GLP-1 RA clinical trials focus on the tau-positive subgroup of patients

Almholt K, Juncker-Jensen A, Laerum OD, Dan K, Johnsen M, Lund LR, et al

Switching to a low-glycemic diet can also help stabilize blood sugar levels as the medications effects taper off

Future directions Future research directions for the use of GLP-1R agonists in the treatment of pain and headache disorders should focus on conducting human trials to evaluate their efficacy and safety, particularly in individuals with comorbid obesity [60]