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Most semaglutide users experience nausea and digestive changes that peak within the first 2-4 weeks, then gradually improve over 8-12 weeks as the body adapts to the medication

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Whatever you call it, the answer is simpler than the worry suggests

Hypothyroidism slows metabolism and makes weight loss harder, but GLP-1 receptor agonists like semaglutide can still be effective when thyroid hormone is optimized

Given the promising results in pre-clinical models (even in the absence of T2D), a unique mechanism of action and multiple age-related reduced disease risks that have been reported with acarbose, support for clinical trials with acarbose focusing on aging-related outcomes and incorporating biological sex, age at treatment initiation, and T2D-dependence within the design is warranted.