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The interstitial cells of cajal (ICCs) serve as the gastrointestinal pacemaker generating and propagating slow waves distally from the greater curve of the stomach body typically at three cycles per minute [26]
Possible mechanisms of renal protection with SGLT2 inhibitors are multifactorial and it is likely that reduction in the glomerular capillary pressure, and reduction in an initial hyperfiltration, can contribute to the reduced albuminuria and prevention of renal impairment [62, 63]
Preclinical research has shown that GLP-1 receptor agonists decrease CGRP expression in chronic migraine models
