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The collaborative meta-analysis examined 12
Semaglutide and other GLP-1 drugs work on appetite and blood sugar, but emerging research suggests they may also influence stress hormone pathways
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Phase 3 Results (REIMAGINE-2, Feb 2026): HbA1c reduction of up to 1.91 points, outperforming semaglutide alone Weight loss of up to 14.2% at 68 weeks in adults with type 2 diabetes and obesity In weight-management evaluation, diabetics achieved ~15.7% weight loss vs 3.1% with placebo Regulatory update: Novo Nordisk filed for FDA approval (Dec 2025) for weight management, supported by the REDEFINE clinical program
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