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Description
The most potent undecapeptide contains two substituted biphenylalanines at the C-terminus and showed surprisingly high potency as a truncated GLP-1 analog (200-fold decrease)

Unlike many hormones or signaling molecules produced elsewhere, MOTS-c is encoded within the mitochondrial genome, specifically the 12S rRNA

Advisory committees rarely derail drugs that have strong efficacy data

At 26 weeks, changes in apoC-III, rather than body weight, were the most accurate predictors of changes in triglyceride levels with tirzepatide, accounting for up to 22.9% of the variability observed.Treatment with tirzepatide demonstrated a dose-dependent decrease in apoC-III and apoB levels, as well as a reduction in the number of large TRLP and small LDLP

John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences

1A) [32]
