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Int J Mol Sci 2019;20:1341.ArticlePubMedPMC 58

Sample sizes were guided by prior experience with the db/db mouse model and were designed to provide 80% power ( = 0.05) to detect biologically meaningful differences in metabolic outcomes

Although GLP-1RAs are known to have action in the brain, it is possible one mechanism by which GLP-1RAs reduce consumption of ingested drugs such as alcohol is, at least in part, through peripheral mechanisms

GLP-1/GLP-1R enhances insulin-promoting factor-1 (PDX-1) responsiveness via the epidermal growth factor receptor (EGFR)/phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT/PKB)/fork head box protein O1 (FOXO1) signaling pathway, thereby maintaining -cell morphological function and promoting the conversion of non- cells to cells