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Regardless of the medication they took, participants also saw other improved health metrics, including reduced blood pressure, blood-fat and blood-sugar levels

They are also, in most cases, clinically insignificant

Many patients notice reduced hunger, earlier fullness, decreased cravings, improved energy levels, and enhanced indicators of health like blood pressure and blood sugar levels

Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work

Tirzepatide goes even further by simultaneously activating both GLP-1 and GIP receptors, creating a dual-agonist effect that no supplement can replicate

For patients, that means PlushCare is somewhat more adaptive than it used to be, but compounding is still not the center of the model