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Pathogenic processes lead to ALS neurodegeneration, including mitochondrial dysfunction, apoptosis, chronic inflammatory reactions mediated by cytokine production, free radical generation, decreased neurogenesis, synaptic loss, synaptic death, excitotoxicity, axonal transport impairment, and neurotrophic factor dysregulation [137]

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Meanwhile, synthetic forms of GLP-1, like semaglutide and tirzepatide, are long acting it takes about seven days to break them down, hence the reason people take weekly injections and lead to significant weight loss

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