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Here, we investigated the role of three C-terminal serine doublets (Ser441/442, Ser444/445, Ser451/452) in the human receptor using site-directed mutagenesis in INS-1 832/3 -cells deleted for endogenous GLP-1R expression

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To overcome this limitation, various modifications and delivery strategies to enhance the pharmacokinetic properties and therapeutic efficacy of GLP-1 analogs have been studied

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Acest studiu este adesea indicat ca baz a interesului pentru semaglutide n modelele metabolice i comportamentale asociate cu apetitul i echilibrul energetic