glp-1/gip agonist Dual GIP/GLP-1 receptor agonists: New advances for treating type-2 diabetes Possible mechanisms of the interaction

Naunyn Schmiedebergs Arch Pharmacol

Kristyn Gumpper-Fedus, PhD, for refining a draft of the Figure into its final form

The eluted sample was quickly neutralized by addition of 1/10 volume of 1 M Tris pH 8.0 and further polished on a size-exclusion chromatography column (Superdex 75, GE healthcare) pre-equilibrated with phosphate-buffered saline (PBS, pH 7.4)

This improved sensitivity may result from lower glucagon levels associated with enhanced insulin action due to improved metabolic control

The two most effective bariatric procedures, Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) both result in enhanced meal-stimulated GLP-1 release which may be contributing to improvements in glucose metabolism and weight loss induced by these procedures

Nevertheless, it is crucial for healthcare providers to diligently monitor for adverse appetite-related responses to these medications