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The challenge appears at 12.5mg and 15mg, where the volume exceeds 1 ml

All of these medications have different dosing schedules and frequencies

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While sulphonylureas potently promote insulin secretion in type-2 diabetic patients via inhibition of K ATP channel activity [[267], [268], [269], [270]], there is no clear evidence that sulphonylureas affect GLP-1 secretion in humans (as reviewed in [266])