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Only injectable compounded semaglutide and tirzepatide are available

The question now is, can we extrapolate that into other patient populations

Krist AH, Davidson KW, et al

PIONEER studies There have been a number of PIONEER studies which have looked at how effective Rybelsus is compared to other medications, for example Liraglutide, in terms of weight loss and reduction in Hb A1c readings

Weight loss was consistent and progressive, starting at 3.93% at three months and reaching 7.87% at twelve months. In addition, several case series studies have demonstrated benefits of GLP-1s in kidney and pancreas transplant recipients, including lowering blood glucose levels and providing renal protective effects. GLP-1 RAs would be advantageous in liver transplant recipients due to their renal clearance, avoiding interference with immunosuppressant drug metabolism

Jens Juul Holst, a Danish GLP-1 expert at the University of Copenhagen, later recalled Engs frustration to Science magazine in 2018: He was extremely frustrated