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Four distinct areas of the lower face typically show the most noticeable changes after GLP-1-induced weight loss: Jowl formation Skin and soft tissue descend below the jawline border, disrupting the smooth jaw contour Pre-jowl sulcus Hollows develop on either side of the chin, creating a stepped appearance along the jaw Marionette lines Deep creases form from mouth corners to the chin as volume loss allows tissue descent Submental changes The area under the chin may appear loose or develop banding as platysma muscle becomes more visible What Are the Best Non-Surgical Treatments for Jawline Support in 2026

Decreasing total body fat, particularly visceral and truncal adipose tissue

This new drug combines semaglutide with amylin and calcitonin receptor agonists

PubMed: 29138605 Abbasi B, et al

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By activating GLP-1 receptors in multiple areas particularly the hypothalamus and vagus nerve this therapy helps reduce appetite, improve glycaemic control, and support healthier eating behaviours