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Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation

Svje et al

GLP-1 receptor agonists enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which normally raises blood sugar), and slow gastric emptying

In biochemical assays, the T98I and W207L/R substitutions did not affect nirmatrelvir activity (Ki value fold changes were 0.3 and 0.7/0.3, respectively), whereas the E166V substitution (which occurs at a Mpro-nirmatrelvir contact residue) reduced nirmatrelvir activity 187-7,700-fold

In addition, GLP-1 agonists delay gastric emptying and inhibit appetite, resulting in decreased food intake and weight loss

Neuropeptide modulation of energy balance studied