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In a clinical trial, people taking 14 mg of Rybelsus once a day lost an average of 3.6 kg after one year

Interestingly, SU-based compounds (such as glimepiride) have been observed to uncouple the glucose dependence of GLP-1R agonists and promote increased rates of hypoglycaemia in patients using GLP-1R agonists together with SU (Table 1) [17,19,4345]

At a weekly dose of 12mg, patients achieved an average weight reduction of 24.2% after 48 weeks, with nearly half losing 25% and one-quarter losing 30%

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