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Semaglutide can lose 10, 20, even 30 percent of its potency without showing any visible change

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Comparison-adjusted funnel plots did not suggest the presence of small-study effect (ESM Figs 4 and 5)

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Now it seems oral small-molecule GLP-1s also dial back eating for pleasure by engaging a brain reward circuit. Given the effect of these drugs on eating for pleasure, future studies could explore whether small-molecule GLP-1s can also suppress cravings for other addictive substances