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Underlying medical conditions: Certain conditions can blunt weight loss responses, including hypothyroidism (a thyroid function test is advisable if not recently checked), Cushing's syndrome or exogenous corticosteroid use, polycystic ovary syndrome (PCOS), and obstructive sleep apnoea (OSA)

DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice

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Semaglutide is a clinically backed medication that helps regulate hunger signals, making it easier to manage portions and cravings

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