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Compounded versions should only be used when legally appropriate, such as during shortages, and only if sourced from an accredited US pharmacy

When patients taking tirzepatide report vaginal spotting, clinicians should systematically evaluate alternative explanations, as the medication itself is not known to cause gynecological bleeding

Am J Med 118(5):2734 Polonsky W, Fisher L, Hessler D, Bruhn D, Best J (2011) Patient perspectives on once-weekly medications for diabetes

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