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A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of bottom-up vs top-down recognition of covariates

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OKeefe JH, Franco WG, OKeefe EL

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This experiment employs an N-terminally directed antibody (polyclonal rabbit antibody directed to the residues at position 714) and a C-terminally directed antibody (monoclonal mouse antibody directed to the residues at position 2633)