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After day 28, the semaglutide molecules may begin breaking down, reducing the drug's effectiveness and potentially creating safety concerns

( 10.1016/j.molmet.2022.101586) [DOI] [PMC free article] [PubMed] [Google Scholar] Pujadas G Varin EM Baggio LL Mulvihill EE Bang KWA Koehler JA Matthews D & Drucker DJ
Is it normal not to lose much (or any) weight in the first week of treatment

The research review on supplements during GLP-1 treatment recommends at least 1 gram daily of combined EPA and DHA

Increasing your dosage too quickly may make side effects worse
CL Answer I have type 2 diabetes
