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Zhang LQ, Zhang W, Li T, Yang T, Yuan X, Zhou Y, Zou Q, Yang H, Gao F, Tian Y, Mei W, Tian XB (2021) GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-kappaB pathway in neuropathic pain mice
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10.1038/s41467-018-04418-y 46 GardenierJ
Together with dihydrobiopterin (BH2), BH4 forms a redox cycle that scavenges endogenous oxidative free radicals, thereby suppressing ferroptosis ( + /NAD(P)H as a cofactor ( De novo synthesis of BH4 depends on three enzymes: GCH1, 6-pyruvoyltetrahydropterin synthase (PTS), and sepiapterin reductase (SPR)
Clinical studies show that stopping the medication often leads to weight regain
