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How dosing patterns affect GLP-1 activity

Genetic evidence that diabetes drug GLP-1 receptor agonists achieve weight loss primarily by reducing fat mass more than muscle

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This helps reduce risk and improves the chance that the treatment plan makes sense

So, while they can work, they also carry a higher risk of inconsistency in dosing, potency, or formulation

Long-acting GLP1-RA have many favorable properties and have clear efficacy data for reducing cardiovascular risks, as well as safety data, for their use in patients with T2D at high cardiovascular risk, including the subset of patients with DKD