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Known as one of the most effective weight loss prescriptions available, Tirzepatide targets two pathwaysGLP-1 and GIP receptorsto enhance appetite control, improve insulin sensitivity, and support sustainable fat loss

Both GLP1R and GIPR regulate nutrient-stimulated insulin secretion, and GIP, like GLP-1, promotes insulin release while supporting -cell proliferation and survival 25

Cold stress, however, did not worsen lipid tolerance in female GLPDRKO mice, suggesting that cold-stress-induced increases in intestinal-triglyceride secretion require either GLP-1R or GLP-2R

Diabetes Care 2018;41:26692701 [DOI] [PMC free article] [PubMed] [Google Scholar] 5.Buse JB, Wexler DJ, Tsapas A, et al

If stinging persists for hours or is accompanied by swelling and warmth beyond 24 hours, contact your healthcare provider