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doi: 10.1016/S0140-6736(18)32279-7

Insulin secretion is stimulated, glucagon and gastric acid secretion are inhibited, and GI transit and motility are decreased by incretin hormones, especially glucagon-like peptide-1 (GLP-1), which is released postprandially from L-cells lining the gut in response to food ingestion (12)

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It is important to note that as with GLP-1 RAs, adverse effects of tirzepatide are dose-dependent

How Semaglutide and Phentermine Work Together for Weight Loss Semaglutide belongs to the GLP-1 receptor agonist class and primarily targets appetite regulation by mimicking glucagon-like peptide-1, a hormone that signals fullness to the brain

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