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GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

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Discover how GLP-1 medications like Wegovy, Saxenda, and tirzepatide interact with contraception, which methods remain reliable, and when additional precautions are needed during weight loss treatment.

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Objective The aim was to compare the risk of incident AF after initiation of GLP-1RAs versus dipeptidyl peptidase-4 inhibitors (DPP4is), as active comparators, in patients with DM