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In most studies, bariatric surgery produces greater total weight loss and more durable results over time compared to medication alone

One preclinical study compared the effects of single GIPR or GLP-1R agonism and combined GLP-1R/GIPR agonism in female APOE*3-Leiden.CETP mice fed a Western-type diet, a well-established mouse model for human-like lipoprotein metabolism and atherosclerotic development, for 10 weeks

Moreover, they were noted to have contrasting or controversial effects on thyroid and pancreatic cancers [20]

In them, patients taking the highest weekly dose (15 mg) of Zepbound lost 48 pounds on average, while those taking the lowest dose (5 mg) lost on average 34 pounds (compared to 7 pounds on placebo) over 72 weeks