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Most protocols begin at a low dose, such as 2.5 mg, once per week

In individuals with elevated BP, SGLT2i lower systolic BP by 39 mmHg [5, 11]

doi:10.1016/j.molmet.2019.07.008 158

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A limitation of the studies investigating expression levels of the cation transporters is that in the absence of adequate specific transporter antibodies quantification of transporter protein was not possible, and correlations were based entirely on mRNA data