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Common side effects reported with retatrutide include: Nausea, vomiting, and diarrhoea (most frequent, particularly during dose escalation) Decreased appetite Constipation Injection site reactions Mild increases in heart rate Cagrilintide has demonstrated a generally well-tolerated profile, with gastrointestinal symptoms also being the most commonly reported adverse effects

Unlike oral Wegovy, orforglipron does not require fasting or strict timing rules

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If retatrutide is authorised, wed expect criteria similar to current NHS policies for weight-management injections: a BMI threshold (with lower thresholds for some ethnic groups), presence of weight-related conditions (e.g., hypertension, OSA, prediabetes), and use alongside structured lifestyle support