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[(accessed on 15 November 2025)];2010 Available online: 77.Dulaglutide: Pharmacodynamics, Mechanism of Action, Toxicity

The critical DILI case occurred during rapid dose-escalation studies designed to determine optimal dosing parameters for potential late-stage development

Activation leads to: Increased satiety signalling in the hypothalamus Slowed gastric emptying Reduced appetite drive Improved insulin signalling This mechanism primarily affects energy intake rather than directly increasing energy expenditure

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97,98 In this prospective observational cohort study published in 2024, which spanned a timeline between 2009 and 2022, the risk of teratology was assessed

doi:10.3803/EnM.2020.35.1.1 Li R, Xia J, Zhang X, et al