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Description

Classic agonists like liraglutide, semaglutide, and dulaglutide mimic the natural signal but keep it on far longer

Glucagon and the Discovery of GLP-1 Incretine would remain undiscovered until 1986 when Habener and Mojsov identified GLP-1(7-37) in intestine as a cleavage product of the precursor for the hormone glucagon (3, 4)

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Nonetheless, it has been demonstrated in foetal rat islets that the insulin transcriptional promoter is glucose-responsive, inducing gene expression almost seven-fold in response to 16 mM glucose [63]