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Structural pharmacology advances are enabling the design of biased agonists and allosteric modulators, which may selectively engage beneficial signaling pathways while reducing side effects [133,134]

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Potential adverse effects include localised skin reactions, flushing, and headache, though safety data specific to patches is lacking

Known side effects include nausea, vomiting, and abdominal discomfort

Jen Cholewka, RD was kind enough to come on #PrimaryCareRAP and tell us what we need to know to guide our patients down this road, because the constipation associated with #semaglutide and #tirzepatide is no joke