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Dehydration can be caused by the above symptoms, so those taking GLP-1s need to drink more water than the average person to stay hydrated

Diabetes Obes Metab (2013) 15(7):593606.10.1111/dom.12050 77 ShirakiAOyamaJKomodaHAsakaMKomatsuASakumaMet alThe glucagon-like peptide 1 analog liraglutide reduces TNF-alpha-induced oxidative stress and inflammation in endothelial cells

Patients often report decreased appetite and reduced cravings for high-calorie foods during this initial phase

Conclusions SG achieved superior weight loss and metabolic improvements compared with semaglutide in this prospective 12-month study, though it was associated with a higher incidence of GERD symptoms

It is MHRA-approved in the UK and has a well-documented safety profile

Tirzepatide has also been established to be efficacious in reducing body weight, with up to 20.9% weight loss seen across the SURMOUNT trials [18, 19, 20, 21]