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Patients experiencing significant cold intolerance should undergo thyroid function testing, complete blood count to assess for anemia (including iron studies), vitamin B12 levels (especially if taking metformin), and metabolic panel to evaluate overall health status

Different quantities (5MG, 10MG, and 15MG) are tested to observe how exposure levels may influence pathway activity
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Dehydration from GLP-1 agonist induced vomiting can progress to acute kidney injury, particularly in individuals with pre existing kidney disease or those taking medications affecting kidney function