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The inclusion criteria explicitly excluded people with diabetes to isolate weight loss effects in the non-diabetic obese population

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Moreover, stable insulin levels can help curb hunger and prevent spikes and crashes in energy, making it easier for individuals to maintain healthy eating patterns and an active lifestyle

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Even mild but persistent symptoms can lead to treatment discontinuation, particularly in non-diabetic individuals using these agents primarily for weight management, who may have lower thresholds for tolerability than diabetic patients