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Financial support : The authors are supported by National Institutes of Health PO1 DK68055-04 and DK67071 (M.C.), NIH 1 U01 DK073975-06 (H.P.P.), and U01 DK074007 (T.L.A.)

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The heterogeneity of study designs, from single case reports to retrospective database analyses, further challenges causal inference

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